Corpus Curare Spiritumque
Researcher at Burnham Institute for Medical Research (Burnham), and the University of California San Diego (UC San Diego), School of Medicine have shown that in mice, transplantation of precursor cells of the pancreas, if the immune system, polytetrafluoroethylene (PTFE). The study, which suggests a new approach for the treatment of type 1 diabetes, was published online April 8 in the journal Transplantation.
The team of researchers has shown that after transplantation, the precursor cells mature into functional beta cells, glucose control response and sugar in the blood. In addition, the study demonstrates that the use of precursor cells, instead of over the obligation of beta cells, improves cell transplant, the chances of success. “The results have exceeded our expectations,” said Pamela ITKIN-Ansari, Ph.D., assistant professor at UC San Diego School of Medicine and Burnham. “We thought that T cells but not in the situation, equipment, cluster around him. But we found no evidence of an active immune response, indicating that the cells of the aircraft were invisible to the immune system. ”
Investigators of the mouse uses two different models in the study. The transplant team mouse cells island in the other mice to show that immune system cells, if PTFE encapsulated. Human cells have been coated with PTFE, and then transplanted into immunocompromised mice to ensure the viability and function of beta cells and precursor cells to mature within the device. ITKIN-Ansari team found that the precursor cells that are not yet fully differentiated, the transplanted cells could regenerate into fully functional beta cells. This has major implications for which, as transplantation of stem cells from tissue should be in the future.
Type 1 diabetes results from an autoimmune response in the body attacks and kills insulin producing beta cells in the pancreas. One of the challenges of cell transplantation therapy for diabetes is the need for immunosuppression in the long term health risks leading. Transplantation of beta cells in an institution, the need for the use of immunosuppressants.
Researcher at Burnham Institute for Medical Research (Burnham), and the University of California San Diego (UC San Diego), School of Medicine have shown that in mice, transplantation of precursor cells of the pancreas, if the immune system, polytetrafluoroethylene (PTFE). The study, which suggests a new approach for the treatment of type 1 diabetes, was published online April 8 in the journal Transplantation.
The team of researchers has shown that after transplantation, the precursor cells mature into functional beta cells, glucose control response and sugar in the blood. In addition, the study demonstrates that the use of precursor cells, instead of over the obligation of beta cells, improves cell transplant, the chances of success. “The results have exceeded our expectations,” said Pamela ITKIN-Ansari, Ph.D., assistant professor at UC San Diego School of Medicine and Burnham. “We thought that T cells but not in the situation, equipment, cluster around him. But we found no evidence of an active immune response, indicating that the cells of the aircraft were invisible to the immune system. ”
Investigators of the mouse uses two different models in the study. The transplant team mouse cells island in the other mice to show that immune system cells, if PTFE encapsulated. Human cells have been coated with PTFE, and then transplanted into immunocompromised mice to ensure the viability and function of beta cells and precursor cells to mature within the device. ITKIN-Ansari team found that the precursor cells that are not yet fully differentiated, the transplanted cells could regenerate into fully functional beta cells. This has major implications for which, as transplantation of stem cells from tissue should be in the future.
Type 1 diabetes results from an autoimmune response in the body attacks and kills insulin producing beta cells in the pancreas. One of the challenges of cell transplantation therapy for diabetes is the need for immunosuppression in the long term health risks leading. Transplantation of beta cells in an institution, the need for the use of immunosuppressants.
