Corpus Curare Spiritumque
Immune cells present at more than spectators at CF may be the key to stop patients with fatal pulmonary disease. New findings from the Stanford University School of Medicine and Lucile Packard Children’s Hospital show that these neutrophil leukocytes signals react strongly patients with cystic fibrosis “the lungs, the development of molecular agitation, which may explain why patients with severe lung damage.
“Cystic fibrosis patients have a problem with the inflammatory reaction in the lungs,” said study senior author Tirouvanziam Rabindra, PhD, a professor of pediatric medicine lungs. “We found that patients with neutrophils sort of schizophrenia, a number of things, with respect to the role of neutrophils manual. ” The research, published online on March 23rd in the Proceedings of the National Academy of Sciences, opening up new targets for the treatment of cystic fibrosis, said Tirouvanziam.
Cystic fibrosis is a genetic disease of the lungs and the digestive system, the more than 30,000 people in the United States. Patients, to children, but life expectancy for a child born today with CF is now 50 to 60 years. Although this is thanks to modern medicines and dietary a good job of controlling the aspects of digestive system disease, patients remain serious problems, respiratory tract. Thick, sticky mucus built into their lungs, inflammation and chronic bacterial infections and the distribution of lung tissue.
For years, scientists thought that cystic fibrosis patients with respiratory tract problems was captured started when bacteria in the excess mucus in his lungs. Showed neutrophils in the lungs in response to invasive bacteria, the thought was there. Neutrophils are supposed to be devouring and destroying bacteria, but a little sore the past and the rapid death of neutrophils in the lungs, the enzymes that destroy tissue, scientists believe.
“This paradigm makes sense in a superficial way, but it has very little to do with the clinical reality,” said Tirouvanziam. A clinical examination in infants with cystic fibrosis has shown that inflammation of the lungs with neutrophils also occurs in the absence of infection to prove. Tirouvanziam And the previous survey has shown, the immune system cells to life remain in the lungs for some time after their arrival.
So what are the neutrophils to Live-in patients’ lungs? The new knowledge on Tirouvanziam team. As a result of the perceived costs patients with cystic fibrosis neutrophils “sputum analysis and fluorescence activated cell sorting The team discovered that the signals from lung tissue of patients were re-neutrophil live with contradictory messages. The first signals from the switch, which Tirouvanziam calls “an old way of happiness” – a chain of command who say that neutrophils that food is abundant, and it is a good time for the cell library protein genes. The second way is one of the cells alarm system in conjunction with inflammation and stress.
“You have received a signal at the same time, we believe, happiness brass signals entirely,” said Tirouvanziam.
His team suspected unreasonable activation of the “opportunity to signal” – the molecular target of rapamycin or mTOR, cellular signal – can trigger neutrophils, large amounts of neutrophil elastase, an enzyme that destroys, that the elastic fibers of the fabric pulmonaire. In healthy people, the ever destructive human neutrophil elastase of neutrophils in the tissues nearby.
Understanding the chronology of events, the enzyme tissue chewing CF is important Tirouvanziam said, because it could help researchers to new therapies for the disease. Drugs now on improving the lung function of patients objective symptoms such as dyspnea, but no change in behavior neutrophils. Tirouvanziam hopes it will soon change.
Immune cells present at more than spectators at CF may be the key to stop patients with fatal pulmonary disease. New findings from the Stanford University School of Medicine and Lucile Packard Children’s Hospital show that these neutrophil leukocytes signals react strongly patients with cystic fibrosis “the lungs, the development of molecular agitation, which may explain why patients with severe lung damage.
“Cystic fibrosis patients have a problem with the inflammatory reaction in the lungs,” said study senior author Tirouvanziam Rabindra, PhD, a professor of pediatric medicine lungs. “We found that patients with neutrophils sort of schizophrenia, a number of things, with respect to the role of neutrophils manual. ” The research, published online on March 23rd in the Proceedings of the National Academy of Sciences, opening up new targets for the treatment of cystic fibrosis, said Tirouvanziam.
Cystic fibrosis is a genetic disease of the lungs and the digestive system, the more than 30,000 people in the United States. Patients, to children, but life expectancy for a child born today with CF is now 50 to 60 years. Although this is thanks to modern medicines and dietary a good job of controlling the aspects of digestive system disease, patients remain serious problems, respiratory tract. Thick, sticky mucus built into their lungs, inflammation and chronic bacterial infections and the distribution of lung tissue.
For years, scientists thought that cystic fibrosis patients with respiratory tract problems was captured started when bacteria in the excess mucus in his lungs. Showed neutrophils in the lungs in response to invasive bacteria, the thought was there. Neutrophils are supposed to be devouring and destroying bacteria, but a little sore the past and the rapid death of neutrophils in the lungs, the enzymes that destroy tissue, scientists believe.
“This paradigm makes sense in a superficial way, but it has very little to do with the clinical reality,” said Tirouvanziam. A clinical examination in infants with cystic fibrosis has shown that inflammation of the lungs with neutrophils also occurs in the absence of infection to prove. Tirouvanziam And the previous survey has shown, the immune system cells to life remain in the lungs for some time after their arrival.
So what are the neutrophils to Live-in patients’ lungs? The new knowledge on Tirouvanziam team. As a result of the perceived costs patients with cystic fibrosis neutrophils “sputum analysis and fluorescence activated cell sorting The team discovered that the signals from lung tissue of patients were re-neutrophil live with contradictory messages. The first signals from the switch, which Tirouvanziam calls “an old way of happiness” – a chain of command who say that neutrophils that food is abundant, and it is a good time for the cell library protein genes. The second way is one of the cells alarm system in conjunction with inflammation and stress.
“You have received a signal at the same time, we believe, happiness brass signals entirely,” said Tirouvanziam.
His team suspected unreasonable activation of the “opportunity to signal” – the molecular target of rapamycin or mTOR, cellular signal – can trigger neutrophils, large amounts of neutrophil elastase, an enzyme that destroys, that the elastic fibers of the fabric pulmonaire. In healthy people, the ever destructive human neutrophil elastase of neutrophils in the tissues nearby.
Understanding the chronology of events, the enzyme tissue chewing CF is important Tirouvanziam said, because it could help researchers to new therapies for the disease. Drugs now on improving the lung function of patients objective symptoms such as dyspnea, but no change in behavior neutrophils. Tirouvanziam hopes it will soon change.
