Cirrhosis of the liver is the seventh leading cause of death in the United States, the lives of 25,000 people per year. It is often the result of alcohol consumption or the effect of hepatitis C, liver and can prevent the filtering of toxins. These toxins accumulate in the blood, and finally reach the brain, where they disrupt neurological and psychological performance, as a condition of hepatic encephalopathy. People with cirrhosis of the liver are also vulnerable to a change in heart rate (decrease in heart rate variability).
Since liver cirrhosis, liver encephalopathy and heart rate variability is well known that in the context of inflammation, the researchers examined the role of cytokines (inflammatory molecules) play.
A recent study by the American Physiological Society indicates that these cytokines may lead to both neurological and cognitive impairment and changes in heart rate in patients with cirrhosis of the liver. The results of the study can also be used for other situations where the variability of heart rate is also decreased, as bipolar disorder and depression after menopause.
The study, “Decreased variability of heart rate in patients with cirrhosis of the liver is on the presence and severity of hepatic encephalopathy,” was directed by Ali R. Mani Sara Montagnese, Clive D. Jackson, Christopher W. Jenkins, Ian Head, C. Robert Stephens, Kevin Moore and Dr. S. Morgan. All are connected with the University College London Medical School, with the exception of Mr. Jackson, with the Royal Free Hospital, London. The study appears in the American Journal of Physiology Gastrointestinal and Liver Physiology.
Three measurements
The study involved 80 patients with cirrhosis of the liver. Sixty-five (81%) patients were due to chronic liver cirrhosis, alcohol abuse, although it has not been any abuse of alcohol, within three months of the study . Among the 15 participants, seven have developed cirrhosis of chronic hepatitis, while the other eight had the disease to other possibilities. Participants, compared to a control group of 11 healthy people.
First, researchers on the presence of hepatic encephalopathy patient’s psyche. You, the different cognitive tests and obtain an electroencephalogram (EEG). After discussion, the participants in the study were regarded as a manifesto of hepatic encephalopathy, hepatic encephalopathy minimal or no encephalopathy.
Second, heart rate variability measured with an electrocardiogram. A healthy heart varies the speed at which it moves by a number of factors. For example, accelerated heartbeat if inhalation and expiration, if a brake. Reduction of heart rate variability – a steady heartbeat – was in the context of systemic inflammation and various neuropsychiatric disorders such as bipolar disorder.
Third, in a subgroup of 18 patients, researchers for the cytokines, which circulate in the blood as part of inflammation. There were among the cytokines interleukin-6, a substance that plays a role in Cell Signaling in the framework of the body responds to inflammation.
In inflammation
If researchers of the study began, they knew that liver cirrhosis leads to encephalopathy, systemic inflammation and reduced heart rate variability. It was not whether and how they were.
Your first major finding is that the variability of heart rate and reduced the presence of hepatic encephalopathy has been strongly linked. The second important finding is that in the blood of inflammatory cytokines (including interleukin-6 levels) eng parallel degree of the impairment neuro-psychiatric and reduction of heart rate variability. This suggests that the inflammatory response plays a role in these problems.
Other results
The researchers also found that:
1.) With patients with cirrhosis of the liver, there were large concentrations of cytokines. However, concentrations were below the level of evidence in healthy volunteers.
2.) There there were no significant differences in heart rate variability between patients with alcohol in the context of patients with cirrhosis of the liver and cirrhosis of the liver, for other reasons, such as chronic viral hepatitis.
3. )The risk of death increases the heart rate variability decreased.
The authors concluded that inflammation plays a role in reducing the heart rate variability and the development of hepatic encephalopathy in patients with cirrhosis of the liver. Of the following, not research, they found that the treatment of hepatic encephalopathy not only mental function, but also improves heart rate variability. This treatment can reduce blood levels of cytokines, which is further evidence of a link between systemic inflammation, psychological and cardiovascular function in this patient group.
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