Gliome malignant brain tumors composed of glial (support) cells of the brain. Gliome are often resistant to chemotherapy. These tumors develop fine extensions, infiltrate normal brain tissue and beyond, tumor cells may be different satellites in the surrounding tissues. Therefore, it is almost impossible to completely tumor tissues of the operation.
However, radical surgery of the tumor is essential to improve the prognosis of patients.
Surgeons are faced with the difficulty of distinguishing between tumor and normal tissues of brain tissue during the operation. Dr. Eva DKFZ Clear of cooperation with doctors and researchers from the Faculty of Medicine, University of Heidelberg, has developed a process to improve neurosurgery. Scientists have used the fact that tumors have increased their energy needs to cover, inter alia, large amounts of blood protein albumin. Researchers from a fluorescent substance (5-aminofluorescein) to albumin, spread throughout the body via the bloodstream, and finally accumulates in the brains of the tumor. Laser effect that the substance filament extensions, the end of the visible tumor.
“More often fade contrast,” says Dr. Eva Frei, “for the resection of tumor may be five to six hours.” Fluorescence brand to albumin, but while the entire operation.
Scientists tested the method of albumin in thirteen patients with malignant gliomas. In nine cases it was possible, tumor tissue fluorescence entirely with the intensity of yellow-green, red light signaling. The researchers calculated that the likelihood of bright fabrics are cells of tumor is 97%.
“Stripping is a huge help for the surgeon, because he or she identify with precision the boundaries between tumor and normal tissues of the brain, in general, very difficult,” says Eva Clair. “Another problem is that the tumor is often pressure on Meninx, so that if it is opened for surgery, the tumor layers, or changes shape.” The new method takes into account these “brain shift” effect and made the exploitation of intra MRTs unnecessary. Other advantages of the new method are as tolerable, inexpensive and easy to use.
The safety and effectiveness of the method of coloring of next year in a larger study of several hospitals. Scientists in a long-term prognosis if the patient is following the new method.
